Collaborative | Empowering | Insightful

Welcome to LeverageBio, where your success is our top priority!

We're here to guide you with tailored solutions To Your biotech Challenges

Meet The Founder

Christian Matranga, PhD Founder and Advisor

My passion lies in driving innovation via robust platforms and methods and fostering collaborative environments to create impactful solutions for clients, patients, and communities.

As a scientist, I tackled challenges in RNA biology, sequencing technology, and genetic medicines, and applied the solutions toward diagnostics and treatments for infectious, immunological, and rare diseases. Early in my career, I made key discoveries in the RNA interference pathway, specifically how small RNAs are assembled into effector complexes and are stabilized through RNA modification. As a research scientist at the Broad Institute, I developed methods for next-generation sequencing (NGS) of viral genomes from clinical samples to generate ‘open access’ data from outbreaks of deadly RNA viruses like Ebola. As it was a consortium research endeavor, I was technical lead on the viral genomics team, supporting collaborations with local and international global leaders. I continued to develop methods for NGS characterization, specifically for single-cell sequencing and analysis of antigen-specific T Cells at Repertoire Immune Medicines. At GreenLight Biosciences and Orbital Therapeutics, I led platform development teams in RNA genetic medicines, pushing the limit of mRNA modalities by making progress through innovation in RNA architecture, protein durability, and nonviral formulation designs. These genetic medicines required an understanding of disease biology for diverse indications such as Hemophilia, Sickle Cell Disease (SCD), and Systemic Lupus Erythematosus (SLE).

As a biotechnology consultant and advisor, I collaborate with organizations to support experimental and construct design, develop and optimize methods, streamline logistics and operations, prepare technical and competitive intelligence analyses, and provide project guidance.

Selected Publications

Matranga et al, Nucleic acid therapeutics for genetic disorders. US 2022/0096525 A1. patent/US20220096525A1/en

Metsky HC, Siddle KJ, et al, Matranga CB. Capturing sequence diversity in metagenomes with comprehensive and scalable probe design. Nature Biotechnology. 10.1038/s41587-018-0006-x

Andersen KG, Shapiro BJ, Matranga CB, et al, Sabeti PC. Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus. Cell. 10.1016/j.cell.2015.07.020

Gire SK, et al, Khan SH, Sabeti PC. Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak. Science. 10.1126/science.1259657

Matranga C, Pyle AM. Double-stranded RNA-dependent ATPase DRH-3: insight into its role in RNA silencing in Caenorhabditis elegans. Journal of Biological Chemistry. 10.1074/jbc.M110.117010

Horwich MD, Li C, Matranga C, et al, Zamore PD. The Drosophila RNA methyltransferase, DmHen1, modifies germline piRNAs and single-stranded siRNAs in RISC. Current Biology. 10.1016/j.cub.2007.06.030

Matranga C, et al, Zamore PD. Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell. 10.1016/j.cell.2005.08.044

FAQs

What services do you offer?

We offer a range of solutions designed to meet your biotech needs including startup logistics and capabilities building; experimental, construct, and assay design; project and CRO guidance; and technical and competitive intelligence analysis. Core functions include (but not limited to) platform technology (e.g. RNA sequencing, bioassays) and therapeutic development (e.g. RNA medicines, gene therapy).


How do I get started?

Getting started is simple. Reach out through our contact form or schedule a call—we’ll walk you through the next steps and answer any questions along the way.


What makes you different?

We combine a thoughtful, human-centered approach with clear communication and reliable results. It’s not just what we do—it’s how we do it that sets us apart.


How can I contact you?

You can reach us anytime via our Get In Touch section below. We aim to respond quickly—usually within one business day.

What Collaborators Are Saying

‘I’ve had the chance to work with Chris Matranga across several stages of my career,  first at the Broad Institute, later at GreenLight, and more recently through his role at LeverageBio. Each time, I’ve been struck by his ability to bring clarity, creativity, and a deep sense of purpose to scientific problem solving.

At Flexomics, Chris played a key role in helping us shape the direction of our platform as we prepared to bring it to a broader audience. He offered thoughtful guidance on how to articulate our value proposition, sharpen our translational impact, and position the work in ways that resonate across both scientific and commercial communities. His depth of experience in immunology, genomics, and therapeutic discovery made his contributions particularly valuable as we refined our strategy.

Chris is a true collaborator, always focused on moving the science forward. I’ve greatly appreciated the chance to work with him and wouldn’t hesitate to recommend him to others building transformative technologies in life sciences.’

Magali S, PhD

Co-Founder & CEO

‘The team from LeverageBio was professional and very knowledgeable. They exceeded all deadlines and delivered high quality work.’

Robert L, PhD

Biotechnology Director

‘I've known and worked with Chris first during his time with GreenLight, and now directly at LeverageBio where he has been helping support me as I look for additional technology platforms for my portfolio. I appreciate Chris' expertise, diligence and collaboration in scoping opportunities and deep diving into the technical details to help shape my thinking and provide me with the key information needed to make solid decisions.’

Brian D, PhD

Senior Technologist, NGO

Get in Touch

Whether you have a question, an idea, or just want to say hello, feel free to reach out—we’re here to help. Please no outside agencies or vendors.